Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia (-) Systemic Features: CANOMAD, DADS-M, Sporadic, late-onset nemaline myopathy Cutaneous-centered: • Systemic capillary leak syndrome (Clarkson's) • Scleromyxedema & Necrobiotic xanthogranuloma (NXG) • POEMS & TEMPI • Schnitzler syndrome • Cryoglobulinemia Renal-centered (ie "MGRS"): • Organized Ig deposits: Ig-related amyloid, Monoclonal immunotactoid GN, Type I cryo GN, Light-chain proximal tubulopathy Non-organized Ig deposits: Ig deposition disease (light chain vs. heavy chain vs. both), Proliferative GN w/ monoclonal Ig deposits, C3 glomerulopathy w/ monoclonal gammopathy • (-) Ig deposits: TMA w/ monoclonal gammopathy Andrew Sanchez M.D. @ASanchez_PS #Monoclonal #Gammopathy #Clinical #Significance #MGUS #Differential #Diagnosis #hematology #oncology
