Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial Workup: CBC with diff, BMP, uric acid, peripheral smear, reticulocyte count, LFTs, LDH, ESR, CRP, iron studies, PT/aPTT Differential Diagnosis: • ↓ Production (↓ reticulocytes, reticulated-plts) • ↑ Destruction + ↓ Production • ↑ Destruction (hemolysis, ↑ reticulocytes, reticulated-plts) • Splenic sequestration (splenomegaly) Matthew Ho, MD PhD @MatthewHoMD #Pancytopenia #Differential #Diagnosis #Algorithm #hematology #workup
