Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity (may be seen when IgM > 4 g/dL) Mixed: • Type 2: Monoclonal IgM (RF) and polyclonal IgG • Type 3 (25%): Polyclonal IgM and polyclonal IgG • Type 2-3: Oligoclonal IgM and polyclonal IgG • Meltzer's triad: purpura, arthralgia, weakness • Liver, kidney (MPGN), peripheral neuopathy, pulmonary (dyspnea, cough, pleurisy) Matthew Ho, MD PhD @MatthewHoMD #Cryoglobulinemia #Classification #Types #hematology #diagnosis
