Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy? → Refer to hematology for workup, including BM Bx Consider reactive thrombocytosis: • Nonmalignant hematologic: Acute blood loss, Acute hemolysis, deficiency anemia, Rebound effect from treatment • Malignancy: Metastatic cancer, Lymphoma, Rebound effect following use of myelosuppressive agents • Inflammatory Conditions: Rheumatologic, Vasculitides, IBD, Celiac disease, Kawasaki, Nephrotic syndrome, POEMS • Reaction to Medications: Vincristine, Epinephrine, Glucocorticoids, IL-1B, ATRA, TPO, TPO-RA • Infections: Chronic infections, TB, Acute bacterial and viral infections • Tissue damage: Thermal burns, Myocardial infarction, Severe trauma, Acute pancreatitis, Post-surgical period • Others: Asplenia/post-splenectomy, Exercise, Allergic reactions Matthew Ho, MD PhD @MatthewHoMD #Thrombocytosis #Platelets #Differential #Diagnosis #Algorithm #hematology
