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Oxygen-Hemoglobin Dissociation Curve Left Shift (↓ O2 unloading to tissue), Left = Lower: • ↓ H+ (↑ pH) • ↓ PCO2 • ↓ 2,3-BPG • ↓ Temperature Right Shift (↑O2 unloading to tissue): • ↑ H+ (Acid) • ↑ PCO2 • Exercise • ↑ 2,3-BPG • High Altitude • ↑Temperature Matthew Ho, MD PhD @MatthewHoMD #Oxygen #Hemoglobin #Dissociation #Curve #pathophysiology #pulmonary #respiratory