Amphotericin B - Pharmacology Summary Sheet Class: Polyene Antifungal Mechanism of Action: • Binds to ergosterol → Complexes and intercalate into cell membrane → pore formation and leakage of intracellular contents → cell apoptosis Pharmacokinetics: • Concentration dependent fungicidal • Distribution: 99% bound to plasma cholesterol • Elimination: Tri-phasic elimination Formulations: Amphotericin B Deoxycholate, Abelcet (Lipid Complex), Ambisome (Liposomal) Ashley & Brooke Barlow PharmD @theABofPharmaC #Amphotericin #AmphotericinB #Pharmacology #ambisome
