Antibiotic Tissue Penetration Blood Brain Barrier: Penicilins (IV), 3rd & 4th generation Cephalosporins (IV), Meropenem, TMP-SMX, Metronidazole, Linezolid, Fluoroquinolones Prostate: Fluoroquinolones Urine: Beta-lactams, Fluoroquinolones (NOT moxifloxacin), TMP-SMX, Aminoglycosides Lungs: Most antibiotics EXCEPT Daptomycin (inactivated by pulmonary surfactant), Aminoglycosides (hydrophilic, low Vd), Vancomycin (low Vd) Intrabdominal: Beta-lactams, Ceftriaxone Bone: Fluoroquinolones Poor Abscess Penetration: Aminoglycoside (inactivated by low pH) Ashley & Brooke Barlow PharmD @theABofPharmaC #Antibiotic #Tissue #Penetration #pharmacology
