Satyendra Dhar, MD @DharSaty · 3 years ago
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Pemphigus vulgaris (PV) is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes. It
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Pemphigus vulgaris (PV) is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes. It is mediated by circulating autoantibodies against keratinocyte cell surfaces. Exposure to certain medications like penicillamine and captopril can trigger PV. Such a trigger can happen through the effects on binding to molecules involved in cell adhesion, influence on enzymes that mediate keratinocyte aggregation, and molecules involved in cell and by stimulating neoantigen formation. In addition, NSAID’s, penicillin, cephalosporins have been associated with drug-induced PV.

IgA pemphigus does not present with oral mucosa blisters. Direct and indirect immunofluorescence can both help to differentiate PV from IgA pemphigus.

Pemphigus foliaceus does not affect the oral mucosa and is less common than PV.

Paraneoplastic pemphigus presents with mucocutaneous vesicles and bullae and can be differentiated from PV using indirect immunofluorescence and immunoblot.

Sayendra HAR md
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#Pemphigusvulgaris #IgApemphigus #Pemphigusfoliaceus #Paraneoplasticpemphigus #autoimmune #Pemphigus
Satyendra Dhar, MD @DharSaty · 3 years ago
Hospital Medicine Clinical Assistant Professor The content and images on this website are provided for educational and informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. The views expressed are those of the authors and do not necessarily reflect those of any affiliated institutions. While efforts are made to ensure accuracy and currency, medical knowledge is continually evolving, and errors or omissions may occur. Users are advised to independently verify information and seek guidance from qualified healthcare professionals for any medical decisions. By using this website, you acknowledge responsibility for your own clinical judgments, and the website and its contributors disclaim any liability arising from the use of its content. 👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
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