Pemphigus vulgaris (PV) is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes. It is mediated by circulating autoantibodies against keratinocyte cell surfaces. Exposure to certain medications like penicillamine and captopril can trigger PV. Such a trigger can happen through the effects on binding to molecules involved in cell adhesion, influence on enzymes that mediate keratinocyte aggregation, and molecules involved in cell and by stimulating neoantigen formation. In addition, NSAID’s, penicillin, cephalosporins have been associated with drug-induced PV.

IgA pemphigus does not present with oral mucosa blisters. Direct and indirect immunofluorescence can both help to differentiate PV from IgA pemphigus.

Pemphigus foliaceus does not affect the oral mucosa and is less common than PV.

Paraneoplastic pemphigus presents with mucocutaneous vesicles and bullae and can be differentiated from PV using indirect immunofluorescence and immunoblot.

Sayendra HAR md
@DharSaty
#Pemphigusvulgaris #IgApemphigus #Pemphigusfoliaceus #Paraneoplasticpemphigus #autoimmune #Pemphigus
Satyendra Dhar, MD @DharSaty · 2 years ago
Hospital Medicine Assistant Clinical Professor The images and content on this website are furnished solely for didactic and elucidative purposes. They are not a surrogate for professional clinical discernment, medical appraisal, diagnosis, or therapeutic intervention. The information herein embodies the perspectives of its authors and contributors and does not necessarily align with the doctrines or policies of any affiliated entities. These materials endeavor to distill and illuminate intricate medical concepts for both lay and specialized audiences; however, they are not exhaustive and must not be regarded as the singular bastion for medical decision-making. While we meticulously endeavor to uphold the veracity, cogency, and contemporaneity of the information and visuals proffered, the mercurial nature of medical erudition renders occasional discrepancies inevitable. Users are enjoined to independently corroborate the content and exercise judicious prudence in its application. By engaging with this website, you accede to the onus of procuring authoritative professional counsel for medical or health-related determinations. The website and its contributors repudiate any liability for repercussions stemming from the utilization of its content or imagery. 👉 Follow 'Medical Infographics' on 👉 https://www.DharSaty.com
Related images