Medications that Can Cause False Positives on Drug Tests Urine drug screens (UDSs) are simple to use, easy to automate and provide rapid results but are subject to cross-reactivity with structurally related and unrelated compounds potentially yielding false-positive results. What medications can cause false positives on drug tests? Amphetamine false positives: • Amantadine • Aripiprazole • Atomoxetine • Brompheniramine • Bupropion • Chlorpromazine • Desipramine • DMAA • Ephedrine • Fluoxetine • Labetalol • Metformin • Ofloxacin • Phentermine • Phenylephrine • Phenylpropanolamine • Promethazine • Pseudoephedrine • Ranitidine • Selegiline • Thioridazine • Trazodone • Nonprescription nasal Antihistamine/decongestant inhalation Cannabinoid false positives: • Cannabidiol (CBD) oil • Hemp food products • HIV medication like efavirenz (Sustiva) • Pain medication like ibuprofen • Proton-pump inhibitors, specifically pantoprazole (Protonix), may cause false-positive for THC • Some vitamin B supplements that come from hemp seed oil Benzodiazepine false positives: • Ibuprofen • Sertraline (Zoloft) • Efavirenz, oxaprozin Cocaine false positives: • Coca tea Buprenorphine false positives: • Amisulpride • Sulpiride • Tramadol Barbiturates false positives: • Ibuprofen (Advil/Motrin) • Naproxen sodium (Aleve) • Sleep aids: doxylamine (Unisom) Methadone false positives: • Diphenhydramine • Doxylamine • Chlorpromazine • Clomipramine • Doxylamine • Quetiapine • Thioridazine • Verapamil Opioids and opiates false positives: • Quinolone antibiotics used to treat bacterial infections like levofloxacin (Levaquin) and ofloxacin • Anti-psychotic medications like quetiapine (Seroquel) • Over-the-counter antihistamines like diphenhydramine (Benadryl) • Poppy seeds LSD false positives: • Ambroxol • Amitriptyline • Benzphetamine • Bupropion • Buspirone • Cephradine • Chlorpromazine • Desipramine • Diltiazem • Doxepin • Fentanyl • Fluoxetine • Haloperidol • Imipramine • Labetalol • Metoclopramide • Prochlorperazine • Risperidone • Sertraline • Thioridazine • Trazodone • Verapamil • Ergonoine, lysergol, brompheniramine, imipramine, methylphenidate, fentanyl, sertraline #False #positive #drug #tests #differential #diagnosis #toxicology #medications #UDS #Utox
