Light, UVB, heat Cholecalciferol vitamin D3 DBP DBP Vitamin D Pool Liver 7-Dehydro-cholesterol DBP → 25-(OH)D 1 Hydroxyl-apatite Bone Fat, bile acids Chylomicrons Vitamin D from food Skin #Parathyroid #PTH secretion Circulating 25-(OH)D DBP Kidney • 25-(OH)D 1,25-(OH,) D 1,25-(OH)w D † Ca?+-retention Metabolite #Bile excretion DBP Low Plasma Ca?+ concentration absorbtion Mucosa Intestine