1 Formation of organic acids Lactate, dissociated fatty acids, acetic acids, etc. Metabolism H formationt 4 Hyperkalemia ЗНСО, Na 2 Mineralization 3 Hypoventilation CO; POA 3- HCO; 6 CO, output # with expiration Diarrhea 5 H*- Proximal tubule Renal failure Distal nephran Hypoaldo- steronism Arg Protein excess HCO HCO absorption and formation 6-Na H excretion HCO, excretion [H*] НСО, w NH, uptake Urea NH. HCO, consumption ft Cys Met 8 [Co] HO pH = pk + log [HCO,] [CO,] <7.35 #Acidosis