Satyendra Dhar, MD @DharSaty · 2 years ago
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Beta-Blocker Overdose/toxicity: • Bradycardia & hypotension (most common). • Myocardial depression & cardiogenic shock (severe overdoses). • Ventricular dysrhythmias (Common with
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Beta-Blocker Overdose/toxicity:

•	Bradycardia & hypotension (most common).
•	Myocardial depression & cardiogenic shock (severe overdoses). 
•	Ventricular dysrhythmias (Common with propranolol & acebutolol). 
•	Others (mental status change, seizure, hypoglycemia, & bronchospasm).
•	Co-ingestions of CCB, TCA, & neuroleptics, increases mortality.
•	Mostly symptomatic < 2 hrs following ingestion, & 
•	Nearly all develop symptoms < 6 hrs. 
•	Delayed toxicity up to 24 hrs after ingestion 
       (Sustained release meds: metoprolol succinate & sotalol).
•	Sotalol prolongs the QTc interval & can lead to Torsades de Pointes.
•	Carvedilol (associated with edema & toxic epidermal necrolysis).
•	IV lipid emulsion therapy for poisoning involving lipophilic medications (eg, propranolol, metoprolol, labetalol)

#Beta-Blocker #Overdose #toxicity #poisoning # Bradycardia # Sotalol #carvedilol #hypoglycemia #glucagon #insulin
Satyendra Dhar, MD @DharSaty · 2 years ago
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