Hashitoxicosis ‘Leakage’ symptoms of active Hashimoto’s disease - Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in Hashimoto’s thyroiditis that causes thyroid swelling. - In the early stages of Hashimoto’s disease, the thyroid may make too much thyroid hormone (hyperthyroidism) before not making enough of it (hypothyroidism). 1. Diffuse infiltration of the thyroid by lymphocytes and plasma cells with subsequent follicular atrophy and scarring 2. ‘Leakage’ symptoms of active Hashimoto’s disease as thyroid is damaged due to thyroid cell inflammation and destruction 3. Eventually thyroid is depleted and hypothyroidism sets in ‘Leakage’ phenomenon can occur in several states: - Post-partum thyroiditis - Silent thyroiditis - Thyroiditis de Quervain/Subacute - Initial ‘active’ state of Hashimoto’s thyroiditis #Hashitoxicosis #Hashimotos #Endocrinology #Diagnosis #Pathophysiology
