Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis, can induce metabolic stress, oxidative stress, and endoplasmic reticulum–related stress to develop in fatty hepatocytes (i.e., lipotoxicity). #Pathophysiology #GI #IM #NASH #NAFLD #NonAlcoholicSteatoHepatitis #NonAlcoholicFattyLiverDisease #NEJM
