On the INR of FFP - why transfusing for INR < 1.7 is futile FFP replaces a relatively fixed percentage of coagulation factors (vertical arrows), the difference is, at higher INR values(below 30% coagulation factors), this corresponds to a large change in INR, however when the INR is lower than 1.7 or so, the same fixed increase in factor concentrations translates to a minor/negligible change in INR. This means that to get an INR back to "normal" an unrealistic amount of FFP would be needed. - Craig Cocchio, PharmD @iEMPharmD #Pharmacology #FFP #Effect #INR #Anticoagulation #Percentage #Transfusion #Graph
