Guillain–Barré syndrome (GBS) (aka: Landry–Guillain–Barré–Strohl syndrome: Most common cause of acute flaccid paralysis Rapidly progressive ascending paralysis & areflexia Autonomic dysfunction, CSF albumin-cytologic dissociation. The sensory and motor systems may be equally affected. The paralysis moves rapidly from lower to upper areas. Differential diagnosis: Myasthenia gravis: Intermittent & worsened by exertion. Multiple Sclerosis: CNS demyelination, hyperreflexia, multiple lesions on MRI, oligoclonal bands in CSF. Botulism: Descending weakness fixed dilated pupils, food/wound toxin exposure & prominent cranial nerve dysfunction with normal sensation. Tick paralysis: Ascending paralysis but spares sensation. West Nile virus: Headache, fever, & asymmetric flaccid paralysis but spares sensation. Transverse myelitis: Pain, weakness, abnormal sensation, urinary dysfunction, sensory level, hyperreflexia, spinal cord lesion on MRI. CIDP: Chronic progression, relapses, requires long-term immunotherapy. Spinal Cord Compression: Hyperreflexia, sensory level, MRI shows mass or compression. #guillainbarresyndrome #flaccidpalsy #compylobacterjejuni #GBS #Landrysyndrome