Systemic Inflammatory Response Syndrome (SIRS) • Non-specific (infections vs non-infectious) • ≥2 of the following: o Temp >38°C or <36°C o HR >90 bpm o RR >20 or PaCO₂ <32 mmHg o WBC >12,000/mm³, <4,000/mm³, or >10% bands Sepsis • Organ dysfunction due to dysregulated host response to infection. • SOFA score increases by ≥2. • qSOFA (≥2 indicates high risk): o Altered mental status (GCS <15) o RR ≥22/min o SBP ≤100 mmHg Severe Sepsis (Obsolete Term in Sepsis-3, 2016) • Sepsis + tissue hypoperfusion/organ dysfunction. Septic Shock • Sepsis + circulatory failure o Hypotension requiring vasopressors (MAP <65 mmHg). o Lactate >2 mmol/L Management (Surviving Sepsis Campaign Guidelines) • Early recognition & treatment (within 1 hour) • IV fluids (30 mL/kg crystalloid in 1st 3 hours) • Broad-spectrum antibiotics ASAP • Vasopressors (norepinephrine) if MAP <65 mmHg • Source control (drain abscesses, remove infected devices) • Supportive care (oxygenation, ventilation, glycemic control, DVT/stress ulcer prophylaxis) #sepsis #sirs #shock #lactate #MAP
