Triptans and supplemental oxygen are first-line abortive therapies for cluster headache. A double-blind, randomized, placebo-controlled crossover trial showed that inhaled high-flow oxygen (12 L per minute) was more effective than placebo in eliminating pain at 15 minutes.11 Complete pain relief was reported in 78% of patients. One low-power study suggested better outcomes from hyperbaric vs. normobaric oxygen, but cost and limited availability inhibit its use.12 No evidence indicates that supplemental oxygen prevents future cluster episodes. #Management #Cluster #Headache #Treatment #Medications
