SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS OR SUBACUTE CUTANEOUS LUPUS - CHRONIC CUTANEOUS LUPUS - ORAL ULCERS OR NASAL ULCERS - NON-SCARRING ALOPECIA - SYNOVITIS INVOLVING 2 OR MORE JOINTS - SEROSITIS - RENAL - NEUROLOGIC - HEMOLYTIC ANEMIA - LEUKOPENIA (<4000/MM3) OR LYMPHOPENIA (<1000/MM3) - THROMBOCYTOPENIA (<100,000/MM3) IMMUNOLOGIC CRITERIA - ANA level above laboratory reference range - Anti-dsDNA antibody level above laboratory reference range (or 2-fold the reference range if tested by ELISA) - Anti-Sm: the presence of antibody to Sm nuclear antigen - Antiphospholipid antibody positivity, as determined by Positive test for lupus anticoagulant - Low complement (C3, C4, or CH50) - Direct Coombs’ test (in the absence of hemolytic anemia #Diagnosis #Rheumatology #SLE #Lupus #Erythematosus #Criteria #SLICC
