When trying to differentiate between the two conditions think “FAST” with Serotonin Syndrome and “SLOW” with Neuroleptic Malignant Syndrome.
Serotonin Syndrome (THINK FAST)
- FAST onset
- FAST movements (agitation, akathisia, HYPERreflexia)
- FAST resolution
Neuroleptic Malignant Syndrome (THINK SLOW)
- SLOW onset
- SLOW movements and HYPOreflexia
- SLOW resolution
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