Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview
Mechanism: Glycopeptide - inhibits cell wall synthesis in Gram positives (different protein than beta lactams β D-Ala-D-Ala).
Spectrum: gram positive agent with activity vs Staph (including MRSA), Strep, and nonVRE Enterococcus. No gram negative coverage. Considered the gold standard for MRSA infections.
Used for: all sorts of situations with suspected or proven gram positive infections from above organisms, including bacteremia, meningitis, PNA, skin/soft tissue, and more. Drug of choice for gram positive infections in patients with severe beta-lactam allergy.
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