Synercid (Quinupristin/Dalfopristin) (IV) - Antibiotics Class Overview Mechanism: “Streptogramins”– inhibits sequential steps in ribosomal synthesis Spectrum: covers MRSA and VRE due to E.faecium. Does not cover E.faecalis (has natural efflux pump). Used for:Not much, as it is very poorly tolerated due to thrombophlebitis at IV siteà generally need central line. Also severe myalgis/arthralgias and lots of drug-drug interactions (CYP450 inhibitor). Poor choice for bacteremia/endocarditis due to static nature. #Pharmacology #Antibiotics #Review #Overview #Synercid #Quinupristin #Dalfopristin
