Anti-C. Difficile - Antibiotics Class Overview 1. Metronidazole – (see anti-anaerobe section above for more details). First-line therapy for first or second episode of mild-moderate C.difficile infection (defined as WBC <15 k, no acute renal failure). 2. Oral Vancomycin – first-line therapy for severe C.diff infection (WBC >15k, or acute renal failure). 3. Fidaxomicin (PO) #Pharmacology #Antibiotics #Review #Overview #CDifficile #Clostridium
