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Rifamycins - Antibiotics Class Overview Include Rifampin, Rifaximin, Rifapentine, Rifabutin. Mechanism: Inhibits bacterial DNA-dependent RNA polymerase (unique mechanism). 1. Rifampin (PO and IV) 2. Rifaximin (PO) #Pharmacology #Antibiotics #Review #Overview #Rifamycins #Rifampin #Rifaximin