SPICE (SPACE) Organisms
- Colloquial acronym for gram-negative bacteria that have inducible, chromosomal beta-lactamase genes known as AmpC.
- Resistance may not be detectable initially, but appears after a period of exposure to beta-lactam antibiotics
- Organisms in this group include:
• Serratia
• Providencia
• "Indole-positive" Proteus species / Acinetobacter
• Citrobacter
• Enterobacter species
- Other organisms in this class include: Acinetobacter, Cronobacter, Edwardsiella, Hafnia, Morganella, and rarely Pseudomonas
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