Algorithm for the Diagnosis of Serotonin Syndrome - Serotonin syndrome is thought to be caused by excess agonism of 5-HT2A Receptors - 60% of patients present within 6 hours of change or administration of medication leading to SS. - Clinical findings with a statistically significant association with SS include: hyperreflexia, inducible clonus, myoclonus, ocular clonus, spontaneous clonus, peripheral hypertonicity, and shivering. - Hyperreflexia, clonus, and rigidity are more prominent in the lower extremities in SS. - Serotonin syndrome must be distinguished from other toxindromes that present similarly: neuroleptic malignant syndrome, anticholinergic poisoning, and malignant hyperthermia - Most cases will resolve after 24 hours with initiation of treatment (see below) and discontinuation of the offending agent. #Diagnosis #Serotonin #Syndrome #Algorithm #Symptoms
