Melanoma Pathogenesis Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation of genetic mutations in melanocyte that activate oncogenes, inactivate tumour suppressor genes and impair DNA repair → melanocyte proliferation, blood vessel growth, tumour invasion, evasion of immune response, metastasis. #Pathophysiology #Oncology #Melanoma #Carcinogenesis
