Unicentric Castleman Disease (UCD) vs Multicentric Castleman Disease (MCD) - Comparison Table Unicentric Castleman Disease (UCD): • Number of lymph nodes involved: One region • Prevalence: More common • Symptoms: Often none or mild (pressure symptoms) • Systemic inflammation: Rare • Associated with HHV-8: No • HIV association: No • Organ involvement: Usually none • Diagnosis: Lymph node biopsy, imaging • Treatment: Surgical removal of affected node (often curative) • Prognosis: Excellent after surgery Multicentric Castleman Disease (MCD): • Number of lymph nodes involved: Multiple regions • Prevalence: Less common, but more serious • Symptoms: Systemic symptoms: fever, night sweats, fatigue • Systemic inflammation: Common • Associated with HHV-8: Often (especially in HIV-positive individuals) • HIV association: Yes, in HHV-8-associated MCD • Organ involvement: Liver, spleen, bone marrow may be affected • Diagnosis: Lymph node biopsy, blood tests, imaging, labs • Treatment: Immunotherapy, antivirals, steroids, chemo • Prognosis: Variable; depends on cause and response to treatment #Unicentric #Multicentric #Castleman #Disease #Comparison #Table #Diagnosis
