Bone Tumor Location within the Skeleton Epiphysis: Only a few lesions are located in the epiphysis, so this could be an important finding. In young patients it is likely to be either a chondroblastoma or an infection. In patients over 20, a giant cell tumor has to be included in the differential diagnosis. In older patients a geode, i.e. degenerative subchondral bone cyst must be added to the differential diagnosis. Metaphysis: NOF, SBC, CMF, Osteosarcoma, Chondrosarcoma, Enchondroma and infections. Diaphysis: Ewing's sarcoma, SBC, ABC, Enchondroma, Fibrous dysplasia and Osteoblastoma. #Bone #Tumor #Location #Localization #Skeleton #Metaphysis #Diaphysis #Epiphysis #Radiology #MSK #Differential #Bony