Pearls for Treatment of Alcohol Use Disorder First-line pharmacotherapies for moderate to severe AUD include naltrexone and acamprosate Common side effects for naltrexone are largely gastrointestinal, and include abdominal pain, nausea, and diarrhea; naltrexone is contraindicated in patients with cirrhosis or who are actively using or at high risk for using opiates Second-line pharmacotherapies include topiramate and gabapentin Their well-known side effect profiles (including memory impairment and somnolence, respectively) at the doses required to achieve efficacy may hinder their broader use in the outpatient setting Novel therapeutic options currently under investigation for AUD include neuromodulation, nalmafene, and psychaedelics #Alcohol #UseDisorder #Management #Treatment #AUD #Therapies #Screening #Addiction #Medications #Pharmacology
