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Lancisi’s Sign in Severe Tricuspid Regurgitation A large venous wave, or Giant V wave, is visible in the jugular vein in patients with tricuspid regurgitation. It is caused by blood flowing backwards into the jugular vein through the incompetent tricuspid valve during ventricular systole. #Lancisis #Sign #Tricuspid #Regurgitation #PhysicalExam #Clinical #Video #Neck #Jugular #Cardiology