Writing a Prescription - Clerkship Starter Pack

NSAID Pharmacology - Amy Chung, MD, MSc @AmyChung #NSAIDs #Pharmacology #COX #Cyclooxygenase

Jaundice - Pathophysiology and Causes - Amy Chung, MD, MSc @AmyChung #Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis

Antiplatelet Drugs and their Actions - Amy Chung, MD, MSc @AmyChung #Antiplatelet #Medications #Pharmacology #Pathophysiology #Drugs #Agents #COX #GIIbIIIa

hematopoiesis - leukocyte maturation tree - Amy Chung, MD, MSc @AmyChung #hematopoiesis #leukocytes #maturation #tree #pathophysiology #Hematology #Progenitor #Cells #WBC #pathology

Coagulation Cascade and Anticoagulant Sites of Action - Amy Chung, MD, MSc https://twitter.com/AmyChung #AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology #Pathophysiology #Mechanisms #DOAC #Hematology

Congenital Heart Disorders - Classification and Differential Algorithm - Amy Chung, MD, MSc @AmyChung #Congenital #Heart #Disorders #Diseases #Classification #Differential #Algorithm #Diagnosis #Peds #Pediatrics #Cardiology #Cyanotic #Pink #Blue

Thyroid Disorders - Differential Diagnosis Algorithm Hypothyroidism: • Hasimoto’s • Radioactive Iodine • Hypopituitarism • Iodine Deficiency • Medications • Surgery • Congenital • Other: Subclinical Hyperthyroidism: • Graves’ • Toxic Nodular • Thyroiditis • Exogenous Hormone • Other - Amy Chung, MD, MSc @AmyChung #Thyroid #Disorders #Differential #Diagnosis #Algorithm #Hypothyroid #Hyperthyroid

Outpatient Hypertension Management Algorithm Monotherapy: • Thiazide/thiazide-like • ACE-I (non-black patients), • ARB • CCB (long acting) • β-blocker (younger than 60 years) Combined: • ACE-I + CCB • ARB + CCB • ACE-I or ARB + Diuretic Hypertensive Urgency/Emergency - Target Organ Damage? • Hypertensive Encephalopathy • Intracranial Hemorrhage • Acute Ischemic Stoke* • Aortic Dissection • Acute Left Ventricular Failure • Acute Coronary Syndrome • Acute Kidney Injury • Pre-Eclampsia • Drugs (Cocaine, Amphetamines, phencyclidine, monoamine oxidase inhibitors) - Amy Chung, MD, MSc @AmyChung #Outpatient #Hypertension #Management #Algorithm #PrimaryCare

Dizziness - Central and Peripheral Causes - Differential Diagnosis Central Causes: • Cerebrovascular: vertebrobasilar, TIA, Wallenburg, Cerebellar infarction and hemorrhage, Brainstem ischemia • Inflammation: Meningitis, Cerebellar abscess • Trauma: cerebellar contusion • Tumours: CPA, posterior fossa, glomous • Toxic • Vestibular Migraine • Multiple Sclerosis • Chiari Malformation Peripheral Causes: • Meniere’s • Labyrinthitis • Acoustic Neuroma • BPPV • Vestibular Neuronitis • Herpes zoster oticus (Ramsay Hunt syndrome) • Labyrinthine concussion • Perilymphatic fistula • Semicircular canal dehiscence syndrome • Cogan's syndrome • Recurrent vestibulopathy • Aminoglycoside toxicity • Otitis media - Amy Chung, MD, MSc @AmyChung #Dizziness #Central #Peripheral #Causes #Differential #Diagnosis #algorithm

Central Nervous System Pharmacology - Somatic and Autonomic Receptors Somatic • Rocuronium -> Non-depolarizing (reversible competitive inhibitors) • Succinylcholine -> Depolarization • Neostigmine - blocks action AchE = increases the levels of Ach (reversal of nondepolarizing agents) • Atropine -> reversible competitive antagonist (anti- cholinergic) Autonomic • Parasympathetic “Rest and Digest” - Ach -> Nicotinic Receptor -> Ach -> Muscarinic Receptor • Sympathetic “Fight or Flight” - Ach -> Nicotinic Receptor -> NE -> Adrenergic Receptor • Sympathetic Innervation of Adrenal Medulla - Ach -> Adrenal Medulla Nicotinic Receptor -> Epinephrine released into blood -> Adrenergic Receptor - Amy Chung, MD, MSc @AmyChung #Central #NervousSystem #CNS #Somatic #Autonomic #Receptors #Pharmacology