Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells 
 - usually at a single site in lymphatic system (node) with progression contiguously with lymphatic system.  
 - Bimodal Age Distribution 
 - better prognosis
 • Nodular Lymphocyte - 5% RS cells absent, lymphocyte predominant (LP) tumour B cells are present
 • Classic - Nodular Sclerosis, Mixed Cellularity, Lymphocyte Rich, Lymphocyte Depletion
Non-Hodgkin lymphomas (NHL) ~60%
 - lymphadenopathy more diffuse, can have extra nodal involvement, irregular pattern of spread, B symptoms not as common 
 - T Cell ~10%
 - B-Cell ~90%
 • Low Grade - Slow growing, Poorly Responsive to Treatment
 • Aggressive/ Intermediate - Faster growing Potential For Cure, Most common, Wide age range
 • High Grade - Very Lethal if untreated, Behave and Treated Like  Acute Leukemias, very high mitotic rate correlated with rapid growth, response to treatment and relapse	

- Amy Chung, MD, MSc @AmyChung 

#Lymphomas #Lymphoproliferative #Disorders #Classification #pathophysiology #Hematology #Diagnosis #NonHodgkin #differential #algorithm
Dr. Gerald Diaz @GeraldMD · 5 years ago
Board Certified Internal Medicine Hospitalist, GrepMed Editor in Chief 🇵🇭 🇺🇸 - Sign up for an account to like, bookmark and upload images to contribute to our community platform. Follow us on IG: https://www.instagram.com/grepmed/ | Twitter: https://twitter.com/grepmeded/
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