Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- usually at a single site in lymphatic system (node) with progression contiguously with lymphatic system.
- Bimodal Age Distribution
- better prognosis
• Nodular Lymphocyte - 5% RS cells absent, lymphocyte predominant (LP) tumour B cells are present
• Classic - Nodular Sclerosis, Mixed Cellularity, Lymphocyte Rich, Lymphocyte Depletion
Non-Hodgkin lymphomas (NHL) ~60%
- lymphadenopathy more diffuse, can have extra nodal involvement, irregular pattern of spread, B symptoms not as common
- T Cell ~10%
- B-Cell ~90%
• Low Grade - Slow growing, Poorly Responsive to Treatment
• Aggressive/ Intermediate - Faster growing Potential For Cure, Most common, Wide age range
• High Grade - Very Lethal if untreated, Behave and Treated Like Acute Leukemias, very high mitotic rate correlated with rapid growth, response to treatment and relapse
- Amy Chung, MD, MSc @AmyChung
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