Amiodarone Toxicity and Monitoring Tremor Ataxia Ocular neuritis Corneal Microdeposits Bradycardia Pulmonary fibrosis Hepatotoxicity Blue-gray skin Photosensitivity Hyperthyroid Hypothyroid Peripheral Neuropathy Pharmacokinetic Considerations - Large Volume of Distribution - Half life = 60 days *delays onset and offset* - Substrate CYP3A4 - Inhibitor of CYP2C9-3A4-2D6 and P-Glycoprotein - Key DDI: digoxin, statins, warfarin, phenytoin, dabigatran #Amiodarone #Toxicity #Monitoring #SideEffects #Adverse #Diagnosis #Management #Pharmacology
