CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment of community-acquired meningitis compared to other antibiotic classes. 1 only FDA-approved for UTI treatment 2 no studies have been published looking at CNS penetration; however has been used successfully in clinical CNS infections 3 overcome by increase in dosages – higher dosages of beta-lactams obtain adequate levels in the CSF and tend to be 1st line agents in bacterial meningitis due to their efficacy and bactericidal properties 4 however has been shown to effectively treat susceptible CNS infections 5 however clinical trials have shown good outcomes when used in treatment of CNS infections - Dr. Milana Bogorodskaya https://twitter.com/foamid #CSF #Penetration #CNS #Antimicrobials #InfectiousDiseases #Pharmacology
