Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009
At least three of the following:
- Fever
- Splenomegaly
- Cytopenia affecting at least two cell lines:
- Hemoglobin <9 g/L
- Platelets < 100 b/L
- Absolute neutrophil count < 1000 b/L
- Hepatitis
At least one of the following:
- Ferritin elevation
- Elevated soluble CD25 (soluble IL2-receptor)
- Hemophagocytosis seen on tissue biopsy
- Low/absent NK-cell activity
Other supportive features (not required)
- Hypertriglyceridemia
- Hypofibrinogenemia
- Hyponatremia
Dr. Josh Farkas @PulmCrit
#HLH #Hemophagocytic #Lymphohistiocytosis #Diagnosis #Criteria #Hematology
