Infantile Spasms Associated with Tuberous Sclerosis 1) Flexor spasms: Sudden flexion of neck, trunk, arms, and legs and contraction of abdominal muscles 2) Extensor spasms: Abrupt extension of the neck and trunk, with abduction or adduction of the arms or legs 3) Mixed flexor-extensor spasms: Flexion of the neck, trunk, and arms, and extension of the legs Clinical • Presentation < 1 year of age • Spasms • Developmental delay Diagnosis • Hypsarrhythmia EEG pattern Management • Corticotropin (ACTH) • Steroids • Benzodiazepines Prognosis • Dependent on development prior to the onset of seizures #Infantile #Spasms #Peds #Pediatrics #Diagnosis
