Diagnostic Algorithm for Non–Small-Cell Lung Cancer (NSCLC). The upper portion of the algorithm shows the morphologic classification of NSCLC based on histologic (hematoxylin and eosin) and cytologic (Giemsa) evaluation. The middle portion of the algorithm shows the molecular analysis for the key treatable oncogenic alterations: EGFR and BRAF V600E mutations and ALK and ROS1 translocations, as well as additional molecular analyses in selected patients. The lower portion of the algorithm shows the assessment of programmed death ligand 1 (PD-L1) expression by means of immunohistochemical staining. #Diagnosis #Honc #Algorithm #NSCLC #PDL1 #NEJM
