Phosphate Binders - Pros and Cons Calcium carbonate (TumsTM) - Most inexpensive, antacid properties useful for reflux and peptic ulcer disease Calcium Acetate (PhosLo) - Relatively inexpensive, less GI calcium absorption compared to Ca carbonate Aluminum hydroxide (Amphogel) - Most effective, potent binder, inexpensive Sevelamer-HCI (RenageI) - Calcium and metal-free binder; may have ancillary benefits such as lipid lowering, uric acid lowering, anti-inflammatory effect. Sevelamer Carbonate (Renvela) - Calcium and metal-free binder; may have ancillary benefits (see above), no metabolic acidosis. - Improved GI tolerance. Lanthanum Carbonate (Fosrenol) - No calcium load. Low pill burden. Magnesium based (MagneBind) - Minimal calcium load. - Anti-constipating. Trivalent iron containing binders (sucroferric oxyhydroxide Velphoro, ferric citrate Auryxia) - No calcium load. Low pill burden - May supply additional Fe, decrease ESA Dr. Edgar V. Lerma @edgarvlermamd - Nephrology Secrets https://amzn.to/34t5DgJ #Phosphate #Binders #Table #Comparison #Pharmacology #Nephrology
