Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks - Arthralgia lasting >= 2 weeks - Typical skin rash: maculopapular, non-pruritic, salmon-pink rash with concomitant fever spikes - Leukocytosis >= 10,000 cells/mm3 with neutrophil polymorphonuclear count >= 80% Minor criteria: - Pharyngitis or sore throat - Lymphadenopathy and/or splenomegaly - Abnormalities in liver enzyme levels - Negative for rheumatoid factor or antinuclear antibodies Exclusion criteria: - Infection, especially sepsis and Epstein-Barr viral infection - Malignant diseases especially lymphomas - Inflammatory disease, especially polyarteritis nodosa #AdultOnset #Stills #Disease #Yamaguchi #Criteria #Diagnosis #Major #Minor #Rheumatology
