Status Epilepticus Continuous seizure activity > 5-10 min OR >= 2 seizures without full recovery First line • Lorazepam 2-4 mg IV • Diazepam 5-10 mg IV • Midazolam 2-4 mg IV (10 mg IM if no IV access) Second line • Phenytoin or fosphenytoin 20 mg/kg IV (Phenytoin max infusion 50 mg/min) (Fosphenytoin max infusion 150 mg/min) • Valproic acid 20 mg/kg IV • Phenobarbital 20 mg/kg IV at 50 mg/minute • Levetiracetam 2,000-4,000 mg over 15 min Third line • Pentobarbital (5-15 mg/kg bolus then 0.5-10 mg/kg/hr infusion) • Propofol (3-5 mg/kg bolus then 1-15 mg/kg/hr infusion #Status #Epilepticus #Management #Neurology #Epilepsy
