Pharmaceutical Management of Hyperthyroidism / Thyroid Storm Beta-Blockers • Decreases sympathetic hyperactivity • Partially blocks peripheral conversion of T4 to T3 (propranolol) Propylthiouracil (PTU) • Blocks synthesis of thyroid hormone • Decreases conversion of T4 to T3 • Faster onset of action than methimazole • Preferred in pregnancy Methimazole • Blocks synthesis of thyroid hormone • Teratogenic Iodine • Inhibits release of stored thyroid hormone • Administer only after synthetic pathway has been blocked by PTU or methimazole (approx. 1 hr) Steroids • Decrease peripheral conversion ofT4 to T3 • May treat autoimmune process in Graves' disease • Treats adrenal insufficiency that may accompany storm #Hyperthyroidism #ThyroidStorm #Management #Pharmacology #Medications #Drugs
