Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
• Lymphomatous infiltration 
• Light chain (LC) cast nephropathy 
• LC deposition disease (LCDD) 
• Heavy chain DD 
• Proximal LC tubulopathy 
• Monoclonal gammopathy of renal significance (MGRS) 
• Secondary Membranous nephropathy 
• Solid tumors 
• Secondary Minimal change disease 
• Hematologic malignancies 

Treatment Related 
• Sepsis, volume depletion 
• Hepatic sinusoidal obstructive syndrome 
• Capillary leak syndrome (Interleukin-2) 
• Tumor lysis syndrome 
• Proximal tubular injury 
• Cisplatin 
• ATN: Imatinib, ifosfomide 
• Crystal nephropathy: Methotrexate 
• AIN: Sorafenib, sunitinib , PD-Ii 
• TMA: Gemcitabine, cisplatin, bevacizumab (VEGFi), TKi 
• Hemorrhagic cystitis -> bladder outlet obstruction (cyclophosphamide) 

#Acute #Kidney #Injury #AKI #Cancer #Oncology #Differential #Diagnosis #Classification #Nephrology
NephSim (www.nephsim.com) @Neph_Sim · 5 years ago
nephsim.com is a free educational tool that uses interactive cases, media, and infographics to teach nephrology topics including glomerular diseases, acid/base disorders, kidney transplant, electrolyte abnormalities, dialysis, & more! https://twitter.com/Neph_Sim
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