Acute Kidney Injury (AKI) in Patients with Cancer
Cancer Related
• Hypercalcemia
• Intravenous contrast
• Lymphomatous infiltration
• Light chain (LC) cast nephropathy
• LC deposition disease (LCDD)
• Heavy chain DD
• Proximal LC tubulopathy
• Monoclonal gammopathy of renal significance (MGRS)
• Secondary Membranous nephropathy
• Solid tumors
• Secondary Minimal change disease
• Hematologic malignancies
Treatment Related
• Sepsis, volume depletion
• Hepatic sinusoidal obstructive syndrome
• Capillary leak syndrome (Interleukin-2)
• Tumor lysis syndrome
• Proximal tubular injury
• Cisplatin
• ATN: Imatinib, ifosfomide
• Crystal nephropathy: Methotrexate
• AIN: Sorafenib, sunitinib , PD-Ii
• TMA: Gemcitabine, cisplatin, bevacizumab (VEGFi), TKi
• Hemorrhagic cystitis -> bladder outlet obstruction (cyclophosphamide)
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