Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12, or folate deficiency • Asplenia Laboratory Interference • Hyperbilirubinemia • Hypertriglyceridemia • Uremia High Glucose Content • RBC Transfusions == False Reduction == Increase RBC turnover • Acute blood loss • Hemolytic anemia • Splenomegaly, Sickle Cell • End-stage renal disease Inhibition of glycosylation • Vitamin C & E Dilutional Effect • RBC Transfusions #False #Elevation #Reduction #HbA1c #HgbA1c #Laboratory #Increase #Decrease #Diagnosis #DM2 #Differential
