Skin Mottling - Skin mottling, a common clinical sign in patients in shock, is a violaceous discoloration of the skin that is due to skin hypoperfusion. It most often manifests in the area around the knees but can also be seen in the ears and fingers. The skin mottling disappeared within 24 hours after treatment (Panel B) #Clinical #Derm #PCC #Mottling #Hypoperfusion #Shock #NEJM