Atopic Dermatitis - Topical Treatment Options First Line: Topical Corticosteroids - High Potency: Betamethasone dipropionate, clobetasol, halobetasol - Medium Potency: Triamcinolone, Fluticasone - Low Potency: Desonide, Hydrocortisone Topical Calcineurin Inhibitors - Elidel (pimecrolimus) - Protopic (tacrolimus) Phosphodiesterase-4 (PDE4) Inhibitor - Eucrisa (crisaborol) Atopic Dermatitis is the most common form of eczema, which affects approximately 20% of children and 3% of adults. After non-pharmacologic options, first-line treatment is topical corticosteroids (TCS). Remember that all TCS are not equal, each has a different level of potency. Aside from TCS, topical calcineurin inhibitors (TCI) are available. Tacrolimus is used in more moderate/severe AD while pimecrolimus is used in mild/moderate AD. Lastly is the newest medication called crisaborole, which is a topical PDE4 inhibitor. You may have seen the commercial for this medication which emphasizes that it can be used on very different skin locations and is "steroid-free" since it's not a TCS. ---- Although crisaborole is a PDE4 inhibitor, it is VERY different than roflumilast (see previous post). Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx #Atopic #Dermatitis #Topical #Treatment #Medications #Pharmacology #Dermatology #Management
