Fibrates - Gemfibrozil and Fenofibrate Mechanism: activates PPAR alpha Lipid Effects: - Decrease TG by 30-50% - Increase HDL by 5-15% - Decrease LDL by 0-20% The Fibrate drug class includes gemfibrozil and fenofibrate. These 2 medications were very commonly used to treat dyslipidemia, specifically hypertriglyceridemia since it has great triglyceride lowering. It's very important to remember not to use either of these medications with a statin, as this increases the risk of rhabdomyolysis. Jarred Prudencio, PharmD - https://www.instagram.com/ambcarerx #Fibrates #Gemfibrozil #Fenofibrate #Pharmacology #LipidEffects
