Drug-Induced Edema Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral edema Tissue edema develops due to one or more of the following: - Increased vascular permeability - Increased hydrostatic pressure - Decreased oncotic pressure in the blood vessels Drug-induced alteration to vascular permeability can occur via numerous mechanisms, some of which include: - Bradykinin (has a very potent effect on blood vessels, leading to vascular permeability) - Histamine release from mast cells - Increased nitric oxide release - Activation of the complement cascade By Dr. Kathryn Watson @Kat_Watson #DrugInduced #Edema #Medication #Causes #Differential #Pharmacology #Pathophysiology
