Carbamazepine Toxicity Carbamazepine (CBZ) is an antiepileptic drug commonly prescribed for seizure disorders, trigeminal neuralgia, neuropathic pain, schizophrenia & bipolar disorder Its mechanism of action involves: - Antagonism of inactivated voltage-dependent Na+ channels - Antagonism of L-type voltage-gated Ca+2 channels - Adenosine receptor agonism (at therapeutic doses) & antagonism (at toxic doses) - Anticholinergic properties (antimuscarinic) - Serotonin reuptake inhibition - Inhibition of glutamate neurotransmission By Dr. Kathryn Watson @Kat_Watson #CBZ #Carbamazepine #Toxicity #Toxicology #Diagnosis #SideEffects #Adverse #Pharmacology
