Gamma hydroxybutyrate (GHB) - Toxicology Clinical presentation - Symptoms of GHB toxicity include: short term anterograde amnesia, drowsiness, coma, bradycardia, hypotension and respiratory depression - Symptoms of CNS depression will usually occur within 15-45 minutes after ingestion. CNS depression will usually persist for 1-3 hours with complete recovery typically within 4-8h - Seizures can occur in both GHB intoxication and withdrawal - Respiratory failure due to sedation can paradoxically result in extreme combativeness at the time of intubation - GHB withdrawal symptoms can include agitation, visual hallucinations and seizure By Dr. Kathryn Watson @Kat_Watson #Gamma #Hydroxybutyrate #GHB #Toxicology #Toxicity #Diagnosis #Management #Pharmacology
